Journal article
Rosettes: a shield for Plasmodium falciparum against artemisinins?
SJ Rogerson
Trends in Parasitology | Published : 2022
Abstract
Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance.
Grants
Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
I thank Leann Tilley and Matt Dixon for helpful discussions. Work in my laboratory is supported by the National Health and Medical Research Council of Australia (GNT1143946) and the Bill & Melinda Gates Foundation (INV-002781) .